Opened 4 years ago
Last modified 3 years ago
#6339 new defect
Chemical library models fail because of too many event iterations or chattering
| Reported by: | Francesco Casella | Owned by: | Francesco Casella |
|---|---|---|---|
| Priority: | high | Milestone: | |
| Component: | Third-Party Libraries | Version: | 1.16.0 |
| Keywords: | Cc: | matejak.marek@… |
Description
Some models in the Chemical library fail during initialization because of too many events, e.g. HemoglobinTitration, while others fail because of chattering during simulation, e.g. Joels57.
@marek, do you have any clue why this could happen?
Change History (4)
comment:1 by , 4 years ago
comment:3 by , 4 years ago
| Milestone: | 1.17.0 → 1.18.0 |
|---|
Retargeted to 1.18.0 because of 1.17.0 timed release.
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Wrong initialization in combination with rapid reaction rates caused high and oscillating flows at start of simulation. I could try to find some realistic values for initialization and/or kinetics parameters of these processes. Even these kinetics parameters has minimal influence to the results (because all is very close to equilibrium during each time), their shift has a great impact in performance of numerical calculation.